Description
AUTOMATED NOCIEPTION ANALYZER (ANA) is designed to automatically detect the occurrence of paw flinches by measuring the movement of a small metal band (0.5 grams) that is placed on the injected paw. The animal is placed without restraint inside the observation chamber over an electromagnetic detector system. Paw flinches are detected by the system and counted automatically using a computer. At the end of the test, a file is written that contains the comment for each observed animal and the number of flinches per minute over time. The base system can accommodate 4 animals at a time. The upgrade package will allow the researcher to measure an additional 4 animals concurrently.
The system as configured includes equipment and supplies to test 4 animals simultaneously and allow 4 more animals to acclimate over the period of testing. The equipment consists of, 4 detection devices, 8 clear plastic observation cylinders, signal acquisition module and BNC input interface with interconnecting cable, automated formalin testing, and data analysis software.
Included with the analysis software, is a program for searching standardized file names, and moving data from these files into an Excel spreadsheet. (template supplied) The Excel spreadsheet calculates the count, mean, standard deviation, standard error and % maximum possible effect (MPE), on the control, drug, and dose data.
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